When I was diagnosed with POTS and IST and Fibromyalgia I knew that there was something causing all of this misery. And I was right! Ll of my research brought me to a POTS diagnosis and when my neurologist told me that I had nerve damage and that if we could find that cause of the nerve damage that healing is possible, I just had to keep looking. I read in December some articles about migraines I think and they somehow lead me to one cause of migraines which is MTHFR(METHYLENETETRAHYDROFOLATE REDUCTASE ) mutations. MTHFR mutations are fairly common. Around 40% of the population have this mutation. I am not a medical person so I will add links to information instead of trying to expalin it all but it amounts to my not being able to use folic acid and other B vitamins. I have what is called COMPOUND HETEROZYGOUS MTHFR mutations( ONE COPY OF THE C677T MUTATION AND ONE
COPY OF THE A1298C MUTATION) If you have CFS or Fibromyalgia or migraines among other issues you should probably be tested for this mutation. The test is a simple blood test (DNA test) and it took a couple weeks to get the results for me. So what to do about this? I avoid folic acid and take methylfolate instead. Along with B12,active B6 and some other supplements. In essence I think that these mutations have caused my nerve damage, pain and other issues. I have started to take my supplements (a month so far) and already I can feel a difference. I have much less achy pain overall. My neuropathy is not much better yet but I am still on very low doses because if I try to raise the dose too fast I feel very ill. This may be caused by a heavy metal burden which I am trying to get tested for. I am hopeful for some healing but I realize that i have had this genetic problem for my whole life so there might also be permanent damage.
If you want to research this for yourself there are a couple websites that are great:
I will try to add more information as I learn but my brain fog is unreal right now so if you want to learn more please do a search or check out those 2 sites.